The pupils of the eyes as a parameter for the developmental stage of Parkinson's

Eye care is also essential during an epidemic

The reactions of the pupils of the eyes, the black circle in the center of the eye that allows light to enter – change according to the progression of Parkinson's disease, according to a study. The results indicate that measuring the reaction of the pupils to stimuli can become in the future a non-invasive way to measure the progress of the disease.

The study was called "Analysis of pupillary results according to disease stage in patients with Parkinson's" and was published in a medical magazine. The pupil is the hole located in the center of the iris, it is the colored part of the eye. The pupil is the organ that allows light to enter the retina, a lining of tissue at the back of the eye that is sensitive to light.


The structure of the iris

The iris is a structure that contracts and expands according to the amount of light available to the eye and needed by the eye to see clearly. Normally the iris regulates the amount of light by controlling the size of the pupil and functions like the aperture of a camera. This movement is known as the pupillary reflex – PLR, and it plays a very significant role in determining the quality of vision, the perceived image and the eye's response to light.

A team of researchers in South Korea conducted a study looking at PLR using a device used to measure the pupil's response to light. The reflex makes it possible to evaluate the functionality of the autonomic nervous system, it is the part of the body that controls involuntary actions such as breathing, digestion, pulse, instinctive reactions. This part is known to be dysfunctional in most Parkinson's patients.

PLR measurement is not an invasive measurement and is therefore relatively simple to implement. The measurement allows the researchers to determine the balance level of the parasympathetic system as well as the sympathetic system – two parts that work together but work in different ways in the body.


Farewell to Parkinson's?

The sympathetic system activates several bodily functions when an imminent threat or major stressor is perceived. In contrast, the wild sympathetic system works to calm the body in non-emergency situations. Measuring the balance between these two systems is a useful test for patients with neurological disorders.


Description of the study

In the current study, patients with Parkinson's were divided into groups. One group included Parkinson's patients in the early stages of the disease and the other group included Parkinson's patients in more advanced stages of the disease. Among 132 patients, 100 were in early stages and 32 were in later stages.

The study found that there is a significant difference between the two groups with regard to the speed of pupil contraction when exposed to light and also a significant difference in the maximum contraction speed. The speed of the contraction is an unequivocal parameter that teaches about the rate of progression of Parkinson's disease and its developmental stage. Thus, these tests can be performed in a non-invasive manner that provides accurate results.

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